Cover Letter 3

Tesfa D. Habtewold, BSc, MSc, CRN
Department of Epidemiology
Department of Psychiatry

University Medical Center Groningen
Hanzeplein 1, 9713 GZ, Groningen
Email: [email protected]
Tel-office: +31 50 361 0738
Mobile: +316 3015 6447

04 December 2019

Yvonne Folkers
Coordinator FSE Fellowship Programme
University of Groningen
Faculty of Science and Engineering
Groningen Research Institute of Pharmacy (GRIP)
Email: [email protected]

Dear Recruiting Team,

I am writing to apply for the Postdoctoral Fellowship in Statistics/Methodology/Pharmacoepidemiology (1.0 FTE) (219177H) in the Groningen Research Institute of Pharmacy (GRIP) at University of Groningen as advertised on the academictransfer (https://www.academictransfer.com/en//). I am a Ph.D. student in University Center for Psychiatry and department of Epidemiology at University of Groningen working under the supervision of professor Richard Bruggeman (Neuropsychiatrist), professor Marike Boezen (genetic Epidemiologist) and Dr. Behrooz Z. Alizadeh (genetic Epidemiologist). I expect to submit my thesis in the coming three to six months and receive my Ph.D. degree in September 2020. My experiences on advanced epidemiological analytical methods (i.e. multilevel analysis, group-based trajectory modeling, machine learning), big and complex data analysis using SAS, R, and STATA, and publishing science along with my six years teaching experience, make me a strong candidate for the postdoctoral fellowship.

The aim of my Ph.D. project is to dissect the clinical and statistical heterogeneity of schizophrenia spectrum disorders by applying data-driven approaches in patients, their unaffected siblings and healthy controls using family-based cohort data in Dutch population. In a cross-sectional study (Study I) involving 1,129 patients with schizophrenia spectrum disorder, I found a significant association between glycated hemoglobin level and use of antipsychotic drugs, high body mass index, blood pressure and cholesterol, age of diseases onset, and polygenic risk score of schizophrenia (PRS_SCZ) and type 2 diabetes (PRS_T2D). In a systematic review (Study II) of 50 cluster- and trajectory-based studies conducted in 30 countries,  I found two to five subtypes of neurocognitive deficits, and positive and negative symptoms/schizotypy with variable long-term trajectories in patients with schizophrenia spectrum disorders, their siblings and healthy people. Numerous environmental factors, including cognitive activity, depressive and somatic symptoms, lifestyle activity, general psychopathology and severity of diseases symptoms  predicted subtypes and longitudinal trajectories. In the 10 years longitudinal cohort study (Study III to V) involving 1,136 patients with schizophrenia spectrum disorders, 1,045 unaffected siblings and 583 healthy controls, I applied a combination of group-based trajectory modelling, polygenic risk score analysis and multilevel analysis to examine heterogeneity and predictors. I discovered cognitive impairment, and positive and negative symptoms are more heterogeneous than currently recognized and associated with poor cardiometabolic health, severity of symptoms, cognitive activity, and genetic susceptibility (i.e. PRS_SCZ).

I see this fellowship as the starting point for implementing knowledge and skills that I gained during Ph.D. study and to further develop my research and teaching skills. Teaching and supervising BSc and MSc students in Pharmacy and Pharmaceutical Sciences, and conducting innovative research will be the top priority during the my postdoctoral work. I received broad training in Clinical and Psychosocial Epidemiology during my master’s degree study in Graduate School of Medical Science at the University of Groningen, The Netherlands. At the same time, I have actively taken (summer)courses and seminar classes in designing epidemiological studies, applied longitudinal data analysis, mixed models for clustered data, group-based trajectory modeling, psychiatric epidemiology and machine learning.

I am excited about the opportunity to be part of a program with broad ranges research and education. Enclosed you will find my CV. Please let me know if I can provide additional information or materials required for my application. Thank you in advance for your time and consideration of my application. I look forward to hearing from you.

Yours sincerely,

Tesfa D. Habtewold